Exosomal PD-L1 detection in cancer predictive biomarker for response to immune checkpoint blockade therapy

Exosomal PD-L1 detection in cancer predictive biomarker for response to immune checkpoint blockade therapy

Programmed death-ligand 1 (PD-L1) carried by tumor-derived exosomes has emerged as a critical mediator of immune evasion and resistance to immune checkpoint blockade therapy. Unlike membrane-bound PD-L1, exosomal PD-L1 is systemically distributed and capable of suppressing T cell activity at distant...

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Bibliographic Details
Main Authors: Tetsuichi Kansha, Xiaojuan Ma, Hao Wang, Xiaotong Yu, Ying Song, Zhengyang Guo, Jiagui Song, Lixiang Xue, Jianling Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
exosomal PD-L1
cancer biomarkers
early detection
liquid biopsy
immune checkpoint blockade
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1603855/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1603855/full

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