Serum Levels of Advanced Oxidation Protein Products and some Liver Function Markers in Chronic Myeloid Leukemia-Chronic Phase Patients Receiving Imatinib or Nilotinib
The treatment of chronic myeloid leukemia has witnessed substantial advancements by the introduction of tyrosine kinase inhibitors. Oxidative stress has been proposed as potential mechanism for resistance to their action. Simultaneously, oxidative stress has a crucial role in hepatic diseases and h...
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College of Pharmacy University of Baghdad
2025-06-01
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| Series: | Iraqi Journal of Pharmaceutical Sciences |
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| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/2932 |
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| author | Ikhlas Khammas Ali Abdulhussain Kasim Bassam Francis |
| author_facet | Ikhlas Khammas Ali Abdulhussain Kasim Bassam Francis |
| author_sort | Ikhlas Khammas |
| collection | DOAJ |
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The treatment of chronic myeloid leukemia has witnessed substantial advancements by the introduction of tyrosine kinase inhibitors. Oxidative stress has been proposed as potential mechanism for resistance to their action. Simultaneously, oxidative stress has a crucial role in hepatic diseases and hepatocytes damage. The study aims to investigate the serum levels and potential correlation of the advanced oxidation protein products (AOPPs), as indicator of oxidative stress, with some markers of liver function. A total of 76 chronic myeloid leukemia-chronic phase patients were enrolled in this transverse, single center study. The enrolled patients were grouped as these receiving imatinib, at an oral dose of 400 mg/ day, and these who failed to clinically respond to imatinib and were switched to nilotinib, at an oral dose of 800 mg/ day. Serum levels of the advanced oxidation products (AOPPs), the hepatic enzymes alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total serum bilirubin (TSB) as well as direct and indirect bilirubin were measured. The enrolled patients in both groups were of comparable age and gender; P˃0.05. Serum ALT level was higher, and serum AOPPs, total and direct bilirubin levels were lower in patients receiving imatinib compared to these receiving nilotinib; there was no significant correlation between the serum levels of AOPPs and that of liver function markers whether in the pooled data of total participants or based on the type of medication used. In conclusion, the oxidative stress, indicated by AOPPs, and bilirubin metabolism is significantly deranged in chronic myeloid leukemia-chronic phase patients receiving nilotinib as compared to these receiving imatinib.
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| format | Article |
| id | doaj-art-5a86f81d58d6443fbb94c38f6d2cb6b0 |
| institution | Matheson Library |
| issn | 1683-3597 2521-3512 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj-art-5a86f81d58d6443fbb94c38f6d2cb6b02025-06-26T05:23:28ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences1683-35972521-35122025-06-0134210.31351/vol34iss2pp40-46Serum Levels of Advanced Oxidation Protein Products and some Liver Function Markers in Chronic Myeloid Leukemia-Chronic Phase Patients Receiving Imatinib or NilotinibIkhlas Khammas0Ali Abdulhussain Kasim1Bassam Francis2Department of Clinical Pharmacy, College of Pharmacy, Al-Bayan University, Baghdad, Iraq.Department of Clinical Laboratory Sciences, College of Pharmacy, University of Baghdad, Baghdad-Iraq.Ministry of Health, Hematology and Bone Transplant Center, Medical City, Baghdad, Iraq. The treatment of chronic myeloid leukemia has witnessed substantial advancements by the introduction of tyrosine kinase inhibitors. Oxidative stress has been proposed as potential mechanism for resistance to their action. Simultaneously, oxidative stress has a crucial role in hepatic diseases and hepatocytes damage. The study aims to investigate the serum levels and potential correlation of the advanced oxidation protein products (AOPPs), as indicator of oxidative stress, with some markers of liver function. A total of 76 chronic myeloid leukemia-chronic phase patients were enrolled in this transverse, single center study. The enrolled patients were grouped as these receiving imatinib, at an oral dose of 400 mg/ day, and these who failed to clinically respond to imatinib and were switched to nilotinib, at an oral dose of 800 mg/ day. Serum levels of the advanced oxidation products (AOPPs), the hepatic enzymes alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total serum bilirubin (TSB) as well as direct and indirect bilirubin were measured. The enrolled patients in both groups were of comparable age and gender; P˃0.05. Serum ALT level was higher, and serum AOPPs, total and direct bilirubin levels were lower in patients receiving imatinib compared to these receiving nilotinib; there was no significant correlation between the serum levels of AOPPs and that of liver function markers whether in the pooled data of total participants or based on the type of medication used. In conclusion, the oxidative stress, indicated by AOPPs, and bilirubin metabolism is significantly deranged in chronic myeloid leukemia-chronic phase patients receiving nilotinib as compared to these receiving imatinib. https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/2932Chronic myloid leukemiaimatinibnilotinibOxidative stress |
| spellingShingle | Ikhlas Khammas Ali Abdulhussain Kasim Bassam Francis Serum Levels of Advanced Oxidation Protein Products and some Liver Function Markers in Chronic Myeloid Leukemia-Chronic Phase Patients Receiving Imatinib or Nilotinib Iraqi Journal of Pharmaceutical Sciences Chronic myloid leukemia imatinib nilotinib Oxidative stress |
| title | Serum Levels of Advanced Oxidation Protein Products and some Liver Function Markers in Chronic Myeloid Leukemia-Chronic Phase Patients Receiving Imatinib or Nilotinib |
| title_full | Serum Levels of Advanced Oxidation Protein Products and some Liver Function Markers in Chronic Myeloid Leukemia-Chronic Phase Patients Receiving Imatinib or Nilotinib |
| title_fullStr | Serum Levels of Advanced Oxidation Protein Products and some Liver Function Markers in Chronic Myeloid Leukemia-Chronic Phase Patients Receiving Imatinib or Nilotinib |
| title_full_unstemmed | Serum Levels of Advanced Oxidation Protein Products and some Liver Function Markers in Chronic Myeloid Leukemia-Chronic Phase Patients Receiving Imatinib or Nilotinib |
| title_short | Serum Levels of Advanced Oxidation Protein Products and some Liver Function Markers in Chronic Myeloid Leukemia-Chronic Phase Patients Receiving Imatinib or Nilotinib |
| title_sort | serum levels of advanced oxidation protein products and some liver function markers in chronic myeloid leukemia chronic phase patients receiving imatinib or nilotinib |
| topic | Chronic myloid leukemia imatinib nilotinib Oxidative stress |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/2932 |
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