Liver‐Secreted Extracellular Vesicles Promote Cirrhosis‐Associated Skeletal Muscle Injury Through mtDNA‐cGAS/STING Axis

Liver‐Secreted Extracellular Vesicles Promote Cirrhosis‐Associated Skeletal Muscle Injury Through mtDNA‐cGAS/STING Axis

Abstract Skeletal muscle atrophy (sarcopenia) is a serious complication of liver cirrhosis, and chronic muscle inflammation plays a pivotal role in its pathologenesis. However, the detailed mechanism through which injured liver tissues mediate skeletal muscle inflammatory injury remains elusive. Her...

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Bibliographic Details
Main Authors: Xiaoli Fan, Yunke Peng, Bo Li, Xiaoze Wang, Yifeng Liu, Yi Shen, Guofeng Liu, Yanyi Zheng, Qiaoyu Deng, Jingping Liu, Li Yang
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
cGAS‐STING
extracellular vesicles
liver fibrosis
mtDNA
skeletal muscle atrophy
Online Access:https://doi.org/10.1002/advs.202410439
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https://doi.org/10.1002/advs.202410439

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