Mosaic loss of chromosome Y in blood is associated with male susceptibility for idiopathic pulmonary fibrosis

Mosaic loss of chromosome Y in blood is associated with male susceptibility for idiopathic pulmonary fibrosis

Abstract Background The prevalence of idiopathic pulmonary fibrosis (IPF) is higher in men, a previously not well-understood sex bias that extends across severity and mortality. Mosaic loss of chromosome Y (mLOY) in blood is male-specific and associated with adverse outcomes, including IPF. In mLOY-...

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Main Authors: Josefin Bjurling, Nicholas W. Chavkin, Jonatan Halvardson, Mark C. Thel, Jonas Mattisson, John S. Kim, Ammar Zaghlool, Shwu-Fan Ma, Fernando J. Martinez, Kevin Anstrom, Imre Noth, Kenneth Walsh, Lars A. Forsberg
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Communications Medicine
Online Access:https://doi.org/10.1038/s43856-025-00966-9
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https://doi.org/10.1038/s43856-025-00966-9

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