A mechanistic basis of fast myofiber vulnerability to neuromuscular diseases

Summary: Neuromuscular diseases such as amyotrophic lateral sclerosis and sarcopenia cause muscle atrophy, which preferentially affects fast-twitch glycolytic myofibers. The mechanisms underlying the susceptibility of fast myofibers to disease remain unclear. To investigate this, we analyzed the tra...

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Bibliographic Details
Main Authors: Matthieu Dos Santos, Svetlana Bezprozvannaya, John R. McAnally, Chunyu Cai, Ning Liu, Eric N. Olson
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cell Reports
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007302
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