Cardioprotective effects of dapagliflozin against the acute cardiotoxic effects of 5-fluorouracil

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Cardioprotective effects of dapagliflozin against the acute cardiotoxic effects of 5-fluorouracil

Background5-Fluorouracil (5-FU) has potential cardiotoxic effects, including direct cardiomyocyte damage, arrhythmia development, and coronary vasospasm. Numerous studies have demonstrated that dapagliflozin (DAPA) possesses cardioprotective properties. Theoretically, DAPA may have the potential to...

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Bibliographic Details
Main Authors:	Mehmet Hakan Uzun, Sebahat Ulusan, Afragül Yönet, Kadir Şeker, Murat Sevimli, Kanat Gülle, Adnan Karaibrahimoğlu, Aliye Kuyumcu, Selçuk Kanat, Mehmet Alagöz, Mevlüt Serdar Kuyumcu
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2025-07-01
Series:	Frontiers in Cardiovascular Medicine
Subjects:	5-fluorouracil cardiotoxicity heart failure SGLT2 inhibitors cardiomyopathy
Online Access:	https://www.frontiersin.org/articles/10.3389/fcvm.2025.1633420/full
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