Macrophage-Secreted U2AF1 Orchestrates Coronary Artery Angiogenesis to Facilitate Myocardial Infarction Repair Through the Regulation of Yap1 Variable Splicing

Macrophage-Secreted U2AF1 Orchestrates Coronary Artery Angiogenesis to Facilitate Myocardial Infarction Repair Through the Regulation of Yap1 Variable Splicing

Myocardial infarction (MI) is characterized by focal necrosis resulting from prolonged myocardial ischemia due to coronary artery obstruction. Vascular reconstruction following MI is crucial for improving cardiac function and preventing recurrent infarction. This study investigates the interaction b...

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Main Authors: Manyu Gong, Haodong Li, Lei Jiao, Tong Liu, Yanwei Zhang, Jie Liu, Siyu Wang, Hao Wang, Dongping Liu, Zhaoyue Li, Zhiyuan Du, Lihua Sun, Lina Xuan, Shihua Lv, Xuewen Yang, Yanying Wang, Yingfeng Tu, Mengmeng Li, Haodi Wu, Xin Li, Xue Feng, Juan Xu, Wenzhi Li, Yong Zhang, Ying Zhang, Baofeng Yang
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Engineering
Subjects:
Angiogenesis
U2 small nuclear RNA auxiliary factor 1
Alternative splicing
Macrophage exosomes
Yes1-associated transcriptional regulator
Online Access:http://www.sciencedirect.com/science/article/pii/S2095809925003005
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