Expert consensus on a multidisciplinary approach for the management of multiple myeloma-related bone disease

Expert consensus on a multidisciplinary approach for the management of multiple myeloma-related bone disease

This consensus on multiple myeloma-related bone diseases (MBDs) underscores the importance of a multidisciplinary approach that encompasses hematology, radiology, orthopedics, and additional specialties to tackle its intricate challenges. MBD, a prevalent and debilitating complication of multiple my...

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Main Authors: Yutong Wang, Qiming Xu, Yuan Li, Yongbin Su, Ling Wang, Xiaoquan Wang, Jian Ge, Hongmei Jing, Yuxing Guo, Yalin Chen, Xianan Li, Jun-ling Zhuang, Jing Tan, Xiaobo Wang, Liye Zhong, Jun Luo, Peng Zhao, Shengjin Fan, Jinhai Ren, Haiping Yang, Heng Mei, Chunyan Sun, Chunrui Li, Xuemei Sun, Xuechun Lu, Guangxun Gao, Zeping Zhou, Yaozhu Pan, Ying Sun, Zhang Hong, Zhiqiang Liu, Yanping Ma, Yi Wang, Wei Sun, Jian Hou, Jianqing Mi, Wenming Chen, Xiaobing Huang, Bingzong Li, Rong Fu, Jumei Shi, Xuehong Ran, Fuling Zhou, Aili He, Min Mao, Zhen Cai, Nan Li, Meng Xu, Xiaojing Yan, Wei Yang, Gang An, Lihua Gong, Lichao Sun, Zhihong Li, Tang Liu, Yanjuan He, Junqiang Yin, Yao Liu, Weifeng Liu, Li Bao
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Cancer Pathogenesis and Therapy
Subjects:
Multiple myeloma
Bone disease
Recommendation
Diphosphonates
Therapeutic effect
Orthopedics
Online Access:http://www.sciencedirect.com/science/article/pii/S2949713224001046
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Summary:This consensus on multiple myeloma-related bone diseases (MBDs) underscores the importance of a multidisciplinary approach that encompasses hematology, radiology, orthopedics, and additional specialties to tackle its intricate challenges. MBD, a prevalent and debilitating complication of multiple myeloma, leads to bone pain, fractures, and skeletal-related events (SREs), which profoundly impact patients’ quality of life. The guidelines offer a thorough framework for diagnosis, treatment, and continual assessment, emphasizing early detection and consistent monitoring using imaging techniques such as positron emission tomography-computed tomography (PET-CT) and magnetic resonance imaging (MRI). Treatment strategies prioritize the careful application of anti-myeloma agents, bisphosphonates, and denosumab to minimize bone loss and decrease SRE risk, complemented by surgical and radiotherapy interventions for structural or pain-related issues. Supportive care measures, including pain management, rehabilitation, nutritional support, and dental evaluations, play a crucial role in enhancing patient outcomes and preserving quality of life. This consensus advocates a standardized, evidence-based approach to managing MBD, ensuring comprehensive and coordinated care for patients.
ISSN:2949-7132

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