Complexity of immunobiology of tumor necrosis factor and novel anti-TNF therapy

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Complexity of immunobiology of tumor necrosis factor and novel anti-TNF therapy

Tumor Necrosis Factor (TNF) was discovered almost 50 years ago as “serum factor” detected in mice following infections or administration of bacterial lipopolysaccharide (LPS), with a remarkable anti-tumor effect. Molecular cloning showed that this activity is mediated by a small protein (17 kDa), wh...

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Bibliographic Details
Main Author:	S. А. Nedospasov
Format:	Article
Language:	Russian
Published:	St. Petersburg branch of the Russian Association of Allergologists and Clinical Immunologists 2023-06-01
Series:	Медицинская иммунология
Subjects:	cytokines anti-cytokine therapy bispecific antibodies mouse models humanization
Online Access:	https://www.mimmun.ru/mimmun/article/view/2860
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