Unfolded protein response in endoplasmic reticulum stress associated with retinal degenerative diseases: A promising therapeutic target

Unfolded protein response in endoplasmic reticulum stress associated with retinal degenerative diseases: A promising therapeutic target

The unfolded protein response is a cellular pathway activated to maintain proteostasis and prevent cell death when the endoplasmic reticulum is overwhelmed by unfolded proteins. However, if the unfolded protein response fails to restore endoplasmic reticulum homeostasis, it can trigger pro-inflammat...

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Bibliographic Details
Main Authors: Hongbing Zhang, Yalin Mu, Hongsong Li, Xiaogang Li
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2026-04-01
Series:Neural Regeneration Research
Subjects:
age-related macular degeneration
autophagy
diabetic retinopathy
endoplasmic reticulum stress
inflammasome
inflammation
mitochondrial diseases
mutation
nuclear receptors
photoreceptor cells
proteostasis
proteotoxic stress
retinal diseases
retinitis pigmentosa
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-24-01124
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