Long-term effectiveness, safety, and liver stiffness dynamics of PBC treatment with obeticholic acid in real-world

Long-term effectiveness, safety, and liver stiffness dynamics of PBC treatment with obeticholic acid in real-world

Background & Aims: Several studies have assessed the short-term effectiveness and safety of obeticholic acid (OCA) in the real-world setting. We aimed to extend knowledge on the real-world effectiveness and safety of OCA treatment by expanding sample size and follow-up, and by exploring chan...

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Main Authors: Francesca Terracciani, Antonio De Vincentis, Daphne D’Amato, Laura Cristoferi, Alessio Gerussi, Pietro Invernizzi, Miki Scaravaglio, Ester Vanni, Daniela Campion, Anna Morgando, Vincenzo Valiani, Vincenzo Boccaccio, Filomena Morisco, Lorenzo Surace, Ilaria Cavalli, Guido Delle Monache, Federico Salomone, Donatella Ieluzzi, Debora Angrisani, Raffaella Tortora, Biagio Cuffari, Alessandra Moretti, Gerardo Nardone, Stefano Fagiuoli, Mauro Viganò, Giovanni Vettori, Federica Cerini, Giancarlo Gimignani, Alberto Mattalia, Fabrizio Pizzolante, Nicoletta De Matthaeis, Cristina Rigamonti, Giulia Francesca Manfredi, Valentina Boano, Paola Begini, Ana Lleo, Francesca Colapietro, Riccardo Plebani, Domenico Alvaro, Rosanna Venere, Elisabetta Degasperi, Marta Borghi, Pietro Lampertico, Edoardo Giovanni Giannini, Sara Labanca, Raffaella Viganò, Federico D'Amico, Antonino Castellaneta, Francesco Squeo, Luca Cadamuro, Luigi Capodicasa, Marco Marzioni, Valerio Buzzanca, Guido Poggi, Alessandro Mussetto, Raffaele Cozzolongo, Francesco Losito, Gaetano Bertino, Maurizio Russello, Mariarita Cannavò, Paolo Scivetti, Maurizio Pompili, Annalisa Tortora, Anna Grazia Niro, Rosa Cotugno, Pietro Pozzoni, Alessia Riva, Luchino Chessa, Michela Miglianti, Giuseppe Cuccorese, Valeria Pace Palitti, Ludovico Abenavoli, Natalia Terreni, Teresa Zolfino, Olivia Morelli, Carlo Saitta, Silvia Casella, Adriano Pellicelli, Maurizia Brunetto, Barbara Coco, Andrea Galli, Fabio Marra, Armando Curto, Annarosa Floreani, Nora Cazzagon, Paolo Rollo, Emanuela Bonaiuto, Loredana Simone, Luigi Muratori, Floriano Rosina, Marco Distefano, Elisa Capello, Valentina Bellia, Rodolfo Sacco, Giuliano Alagna, Leonardo Baiocchi, Lory Saveria Crocé, Chiara Ricci, Paolo Poisa, Antonio Izzi, Sara Boninsegna, Vincenza Calvaruso, Marco Carbone, Umberto Vespasiani-Gentilucci, Giulia Di Pasquale, Paolo Gallo, Cossiga Valentina, Falbo Elisabetta, Tatonetti Riccardo, Musumeci Martina, Christou Chrysanthi, Paolo Villa, Eugenia Pesatori, Alessandro Loglio, Alessandro Conforti, Valentina Feletti, Alessandra Garriba, Evelise Frazzetto, Sara Alecci, Annalisa Ardiri, Martina Costanzo, Francesca Romana Ponziani, Francesca Fianchi, Niccolò Bina, Francesca Zani, Barbara Omazzi, Olga Falco, Jessica Piroddu, Anna Rocca, Paola Carnì, Giuseppe Grassi, Francesco Pezzato, Erica D'Ovidio, Matteo Peviani, Alessandro Bellia, Maria Cristina Sapere, Massimiliano Loreno, Masutti Flora, Fusaro Lisa, Riccardo Perbellini, Roberta Soffredini, Concetta Pitrone, Roberto Filomia, Alba Rocco, Pasquale De Crescenzo, Pasquale Piscitelli, Francesca Toffolon, Fabiana Marchetti, Alessandro Inno, Marco Guarracino, Giovan Giuseppe Di Costanzo, Nicola Alessi, Maria Cristina Neglia, Scudu Chiara
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:JHEP Reports
Subjects:
primary biliary cholangitis
obeticholic acid
real-world evidence
cirrhosis
overlap syndrome
liver stiffness measurement
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555925001260
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http://www.sciencedirect.com/science/article/pii/S2589555925001260

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