SENP1-Sirt3 axis regulates type II alveolar epithelial cell activity to confer resistance against oxidative damage in lung tissue

SENP1-Sirt3 axis regulates type II alveolar epithelial cell activity to confer resistance against oxidative damage in lung tissue

Oxidative damage exacerbates pulmonary fibrosis by impairing alveolar type II epithelial (AT2) cell function. This study demonstrates that the SUMO-specific protease 1 (SENP1)-Sirtuin 3 (Sirt3) axis, critical for mitochondrial redox regulation, is suppressed in AT2 cells during lung injury. In bleom...

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Bibliographic Details
Main Authors: Mingming Zhang, Xin Lin, Jianli He, Yong Zuo, Qiuju Fan, Innocent Agida, Hongsheng Tan, Caiying Zhu, Jinke Cheng, Tianshi Wang
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
SENP1-Sirt3 axis
AT2 cell
Oxidative damage
Mitochondria
Lung fibrosis
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002654
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http://www.sciencedirect.com/science/article/pii/S2213231725002654

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