Synapses and dendritic spines are eliminated in the primary visual cortex of mice subjected to chronic intraocular pressure elevation

Synapses and dendritic spines are eliminated in the primary visual cortex of mice subjected to chronic intraocular pressure elevation

Synaptic plasticity is essential for maintaining neuronal function in the central nervous system and serves as a critical indicator of the effects of neurodegenerative disease. Glaucoma directly impairs retinal ganglion cells and their axons, leading to axonal transport dysfuntion, subsequently caus...

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Bibliographic Details
Main Authors: Xinyi Zhang, Deling Li, Weiting Zeng, Yiru Huang, Zongyi Zhan, Yuning Zhang, Qinyuan Hu, Lianyan Huang, Minbin Yu
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2026-03-01
Series:Neural Regeneration Research
Subjects:
chronic ocular hypertension
dendritic spines
glaucoma
glial cells
neuroinflammation
neuron
retinal ganglion cells
synaptic plasticity
visual cortex
visual pathway
Online Access:https://journals.lww.com/10.4103/NRR.NRR-D-24-00394
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