Investigating SAR Insights into Royleanones for P-gp Modulation

Investigating SAR Insights into Royleanones for P-gp Modulation

Multidrug resistance (MDR) presents a significant challenge in modern pharmacotherapy, greatly diminishing the effectiveness of chemotherapeutic agents. A primary mechanism contributing to MDR is the overexpression of P-glycoprotein (P-gp), also known as MDR1, encoded by the ABCB1 gene, which hamper...

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Bibliographic Details
Main Authors: Gabrielle Bangay, Vera M. S. Isca, Florencia Z. Brauning, Jelena Dinic, Milica Pesic, Bernardo Brito Palma, Daniel J. V. A. dos Santos, Ana M. Díaz-Lanza, Eduardo Borges de Melo, João Paulo Ataide Martins, Patrícia Rijo
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Chemistry Proceedings
Subjects:
SAR
royleanones
P-gp
multidrug resistance
<i>Plectranthus</i>
Online Access:https://www.mdpi.com/2673-4583/16/1/35
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