The efficacy and safety of neoadjuvant and adjuvant chemo(radio)therapy combined with surgery in patients with locally advanced rectal cancer harboring defective mismatch repair system: a large-scale multicenter propensity score analysis

The efficacy and safety of neoadjuvant and adjuvant chemo(radio)therapy combined with surgery in patients with locally advanced rectal cancer harboring defective mismatch repair system: a large-scale multicenter propensity score analysis

BackgroundFor locally advanced rectal cancer (LARC) with a deficient mismatch repair/microsatellite instability-high (dMMR/MSI-H), particularly in patients not eligible for immunotherapy, the optimal treatment remains undetermined. This study was to evaluate the efficacy and safety of surgery, surge...

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Main Authors: Huan-Huan Wang, Yuan-Yuan Yan, Hong-Yu Zeng, Yong Wang, Ke-Min Ni, Xin-Ru Yu, Jin-Ming Shi, Hong-Li Li, Jun-Feng Wang, Zhi-Yong Yuan, Qing-Lian Wen, Nicholas G. Zaorsky, Chun-Ze Zhang, Feng-Lin Zang, Mao-Bin Meng
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
locally advanced rectal cancer
deficient mismatch repair
surgery
chemotherapy
chemoradiotherapy
progression-free survival
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1626438/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1626438/full

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