A proximity-labeling-based approach to directly detect mRNA delivery to specific subcellular locations

A proximity-labeling-based approach to directly detect mRNA delivery to specific subcellular locations

Messenger RNA (mRNA) therapeutics show considerable promise but face delivery challenges, as effective cytosolic entry and subsequent translation are normally limited by endosomal entrapment. While various approaches have been used to investigate determinants of effective RNA delivery, these methods...

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Bibliographic Details
Main Authors: Alfredo D. Smart, Merryn E. Hughes, Angela Downie Ruiz Velasco, Naoto Hori, Snow Stolnik, Catherine L. Jopling
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Delivery Strategies
mRNA delivery
endoplasmic reticulum
signal peptide
proximity biotinylation
APEX
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125001568
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http://www.sciencedirect.com/science/article/pii/S2162253125001568

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