Temozolomide-based radio-chemotherapy for newly diagnosed pediatric high-grade gliomas (HIT-HGG-2007): A prospective, multicenter, single-arm, phase II trial

Temozolomide-based radio-chemotherapy for newly diagnosed pediatric high-grade gliomas (HIT-HGG-2007): A prospective, multicenter, single-arm, phase II trial

Background: The HIT-HGG-2007 trial investigated temozolomide (TMZ) radio-chemotherapy for pediatric patients with high-grade gliomas (pHGG) to demonstrate therapeutic non-inferiority compared to previous intensive radio-chemotherapy regimens (HIT-GBM-C/-D). Methods: Between June 2009 and December 20...

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Main Authors: Michael Karremann, Thomas Perwein, André O. von Bueren, Gerrit H. Gielen, Martin Benesch, Gunther Nussbaumer, Lea L. Friker, Andreas Waha, Dominik Sturm, David T.W. Jones, Olaf Witt, Stefan M. Pfister, Matthias Eyrich, Ulrich W. Thomale, Chiara Valentini, Mechthild Krause, Stefaan W. Van Gool, Michael C. Frühwald, Pablo Hernaiz-Driever, Martin Ebinger, Georg Ebetsberger-Dachs, Roman Crazzolara, Christine Haberler, Felix Sahm, Nicolas U. Gerber, Carl Friedrich Classen, Ronald Sträter, Kornelius Kerl, Stefan Rutkowski, Gudrun Fleischhack, Miriam van Buiren, Rolf-Dieter Kortmann, Christian Hagel, Gabriele Calaminus, Andreas Faldum, Monika Warmuth-Metz, Brigitte Bison, Torsten Pietsch, Marion Hoffmann, Robert Kwiecien, Christof M. Kramm
Format: Article
Language:English
Published: Elsevier 2025-12-01
Series:EJC Paediatric Oncology
Subjects:
Children
Glioblastoma
High-grade-glioma
MGMT
Survival
Online Access:http://www.sciencedirect.com/science/article/pii/S2772610X25000972
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