Exceptional Uptake, Limited Protein Expression: Liver Macrophages Lost in Translation of Synthetic mRNA

Exceptional Uptake, Limited Protein Expression: Liver Macrophages Lost in Translation of Synthetic mRNA

Abstract Most gene therapies exert their actions via manipulation of hepatocytes (parenchymal cells) and the reasons behind the suboptimal performance of synthetic mRNA in non‐parenchymal cells (NPC) such as Kupffer cells (KC), and liver macrophages, remain unclear. Here, the spatio‐temporal distrib...

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Main Authors: Cheng Lin, Adrian Kuzmanović, Nan Wang, Liangliang Liao, Sabrina Ernst, Christian Penners, Alexander Jans, Thomas Hammoor, Petra Bumnuri Stach, Mona Peltzer, Ines Volkert, Elisabeth Zechendorf, Reham Hassan, Maiju Myllys, Christian Liedtke, Andreas Herrmann, Gurudas Chakraborty, Christian Trautwein, Jan Hengstler, Gerhard Müller‐Newen, Junqing Wang, Ahmed Ghallab, Matthias Bartneck
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Advanced Science
Subjects:
hepatocytes
lipid nanoparticles
non‐parenchymal cells
ploidy
synthetic mRNA
Online Access:https://doi.org/10.1002/advs.202409729
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https://doi.org/10.1002/advs.202409729

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