FMRP silencing via siRNA lipid nanoparticles to reprogram the tumor microenvironment and enhance anti-PD-1 efficacy in triple-negative breast cancer

FMRP silencing via siRNA lipid nanoparticles to reprogram the tumor microenvironment and enhance anti-PD-1 efficacy in triple-negative breast cancer

Fragile X mental retardation protein (FMRP), encoded by the Fmr1 gene, is notably upregulated in various malignancies, including triple-negative breast cancer, pancreatic ductal adenocarcinoma, and colon carcinoma, and potentially mediates immune evasion through multiple mechanisms. Here a small int...

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Bibliographic Details
Main Authors: Letian Bai, Xinyan Hao, Wenjie Xu, Hai Huang, Mengen Guo, Yanwen Zhang, Daxiong Xiang, Guoping Yang, Junyong Wu, Chuanpin Chen
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Materials Today Bio
Subjects:
Lipid nanoparticle (LNP)
Fragile X mental retardation protein (FMRP)
siRNA delivery
PD-1
Tumor microenvironment
Immunotherapy
Online Access:http://www.sciencedirect.com/science/article/pii/S2590006425006453
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http://www.sciencedirect.com/science/article/pii/S2590006425006453

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