hCCL19-expressing recombinant Newcastle disease virus boosts CAR T cell infiltration and efficacy in solid tumor

hCCL19-expressing recombinant Newcastle disease virus boosts CAR T cell infiltration and efficacy in solid tumor

Background Chimeric antigen receptor (CAR) T cell therapy has revolutionized the treatment of hematological malignancies; however, it faces significant challenges in treating solid tumors, including limited immune infiltration into tumor tissues and immunosuppressive tumor microenvironment. Oncolyti...

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Main Authors: Qian Li, Ling Wang, Man Liu, Ze-kun Liu, Wen Yin, Can Li, Lan-Ting Feng, Ren-Yu Zhang, Wen-Liang Li, Hai-Jiao Yang, Yu-Le Yong, Xiang-Min Yang, Hong-Yong Cui, Ling-Min Kong, Zhi-Nan Chen, Huijie Bian, Ding Wei
Format: Article
Language:English
Published: BMJ Publishing Group 2025-07-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/7/e011783.full
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https://jitc.bmj.com/content/13/7/e011783.full

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