FTO O-GlcNAcylation promotes TRIM21-mediated FTO ubiquitination degradation to sustain the negative feedback control of macrophage inflammation

FTO O-GlcNAcylation promotes TRIM21-mediated FTO ubiquitination degradation to sustain the negative feedback control of macrophage inflammation

IntroductionThe fat mass and obesity-associated protein (FTO), a key RNA N6-methyladenosine (m6A) demethylase, has been highlighted for its important role in inflammatory response. Emerging evidences link the O-GlcNAcylation to numerous human diseases, particularly inflammation. However, the specifi...

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Bibliographic Details
Main Authors: Lu Zhang, Min Liu, Yan Xie, Bi-Feng Yuan, Zhiyong Peng, Jun Xiong, Xiao-Lian Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
FTO
O-GlcNAcylation
ubiquitination
macrophage
inflammatory response
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593243/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1593243/full

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