Next-Generation Sequencing Techniques to Diagnose Culture-Negative Subacute Native Aortic Endocarditis

Next-Generation Sequencing Techniques to Diagnose Culture-Negative Subacute Native Aortic Endocarditis

Next-generation sequencing might improve diagnosis of infective endocarditis. A case in Switzerland was initially attributed to Solobacterium moorei bacteria. Metagenomic analysis of the affected heart valve detected Streptococcus gordonii, but not S. moorei, illustrating that the results of molecu...

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Bibliographic Details
Main Authors: Delphine Vetterli, Morgana Zennaro, Virginie Tacchini, Joannes Alexander Lobrinus, Virginie Prendki, Vladimir Lazarevic, Jacques Schrenzel
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2025-07-01
Series:Emerging Infectious Diseases
Subjects:
endocarditis
bacteria
streptococci
infective endocarditis
sequence analysis
cell-free nucleic acid
Online Access:https://wwwnc.cdc.gov/eid/article/31/7/24-1739_article
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Summary:Next-generation sequencing might improve diagnosis of infective endocarditis. A case in Switzerland was initially attributed to Solobacterium moorei bacteria. Metagenomic analysis of the affected heart valve detected Streptococcus gordonii, but not S. moorei, illustrating that the results of molecular detection can vary depending on sampling time and anatomic site.
ISSN:1080-6040
1080-6059

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