Astrocytic abnormalities in brain-specific Cacna1c-deficient mice: Implications for BBB impairment in neuropsychiatric diseases associated with CACNA1C mutations

Astrocytic abnormalities in brain-specific Cacna1c-deficient mice: Implications for BBB impairment in neuropsychiatric diseases associated with CACNA1C mutations

Intronic genetic variants within the CACNA1C gene, which encodes the pore-forming alpha 1c subunit of the Cav1.2 L-type calcium channel, are significant risk factors for a multitude of neuropsychiatric disorders. In most cases, these intronic SNPs have been associated with reduced CACNA1C expression...

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Bibliographic Details
Main Authors: Yeojung Koh, Maria Noterman-Soulinthavong, Anusha Bangalore, Uapingena P. Kandjoze, Zea Bud, Kamryn L. Noel, Hami Lee, Kathryn Franke, Coral J. Cintrón-Pérez, Anjali M. Rajadhyaksha, Eric B. Taylor, Andrew A. Pieper
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:Channels
Subjects:
Calcium
Cav1.2
CACNA1C
aquaporin 4
AQP4
neuropsychiatric disease
Online Access:https://www.tandfonline.com/doi/10.1080/19336950.2025.2523788
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https://www.tandfonline.com/doi/10.1080/19336950.2025.2523788

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