Proinflammatory transcriptomic and kinomic alterations in astrocytes derived from patients with familial Alzheimer's disease

Proinflammatory transcriptomic and kinomic alterations in astrocytes derived from patients with familial Alzheimer's disease

Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by profound neuronal and cognitive decline, with increasing evidence implicating astrocyte dysfunction in disease pathology. While traditional therapeutic approaches have primarily targeted neurons, the crucial r...

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Main Authors: Benjamin Siciliano, Nicholas D. Henkel, William G. Ryan V, Ali Sajid Imami, John M. Vergis, Chongchong Xu, Taylen O. Arvay, Smita Sahay, Priyanka Pulvender, Abdul-rizaq Hamoud, Chadwick Hales, Robert E. McCullumsmith, Zhexing Wen
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Brain, Behavior, & Immunity - Health
Subjects:
Alzheimer's disease
Familial Alzheimer's disease
Astrocyte dysfunction
Multiomic analysis
Transcriptomics
Kinomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2666354625001024
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