Spectrum of VHL mutations in clear cell renal cell carcinoma

Spectrum of VHL mutations in clear cell renal cell carcinoma

The VHL gene alterations are the early and characteristic feature of clear cell renal cell carcinoma (ccRCC). We have examined VHL mutations in sporadic 98 ccRCC cases to evaluate their localization in relation to functionally important motifs of the VHL protein. The DNA samples were obtained from s...

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Bibliographic Details
Main Authors: N. N. Mazurenko, I. V. Tsyganova, V. V. Strelnikov, A. V. Balbutsky, T. F. Malivanova, E. B. Kuznetsova, V. A. Draudin-Krilenko, O. V. Shangina, A. F. Mukeria, V. B. Matveev, D. G. Zaridze
Format: Article
Language:Russian
Published: ABV-press 2020-11-01
Series:Успехи молекулярной онкологии
Subjects:
clear cell renal cell carcinoma
vhl mutations
sanger sequencing
ngs analysis
Online Access:https://umo.abvpress.ru/jour/article/view/290
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