White Matter Hyperintensities Mediate the Negative Impact of HbA1c Levels on Cognitive Function

White Matter Hyperintensities Mediate the Negative Impact of HbA1c Levels on Cognitive Function

Background: Type 2 diabetes is linked to impaired cognitive function, but the underlying mechanisms remain poorly understood. As white matter hyperintensities (WMHs) are common in diabetes and associated with vascular brain injury, we investigated whether WMH burden mediates the relationship between...

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Main Authors: Rudolph Johnstone, Ida Rangus, Natalie Busby, Janina Wilmskoetter, Nicholas Riccardi, Sarah Newman-Norlund, Roger Newman-Norlund, Chris Rorden, Julius Fridriksson, Leonardo Bonilha
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Brain Sciences
Subjects:
diabetes
cognitive impairment
white matter hyperintensities
dementia
brain aging
Online Access:https://www.mdpi.com/2076-3425/15/7/692
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https://www.mdpi.com/2076-3425/15/7/692

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