In vitro models for biological activity evaluation of a new antifibrotic drug based on the vesicular fraction of the human mesenchymal stromal cells secretome

In vitro models for biological activity evaluation of a new antifibrotic drug based on the vesicular fraction of the human mesenchymal stromal cells secretome

Introduction. The vesicular fraction of human mesenchymal stem/stromal cells (EV MSCs) secretome can be considered as a pharmaceutical substance for the biological drug development to treat fibrotic diseases. Biological drugs quality control requires standard tests using simple validable methods. Ad...

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Bibliographic Details
Main Authors: U. D. Dyachkova, N. A. Basalova, M. A. Vigovskiy, A. Yu. Efimenko, O. A. Grigorieva
Format: Article
Language:Russian
Published: LLC Center of Pharmaceutical Analytics (LLC «CPHA») 2023-09-01
Series:Разработка и регистрация лекарственных средств
Subjects:
biological drug
extracellular vesicles
mesenchymal stem/stromal cells (mscs)
specific activity
Online Access:https://www.pharmjournal.ru/jour/article/view/2155
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