Design, Synthesis, and In Vitro Evaluation of 4-(Arylchalcogenyl)methyl)-1H-1,2,3-triazol-1-yl-menadione: Exploring Their Potential Against <i>Tuberculosis</i>

Design, Synthesis, and In Vitro Evaluation of 4-(Arylchalcogenyl)methyl)-1H-1,2,3-triazol-1-yl-menadione: Exploring Their Potential Against <i>Tuberculosis</i>

<b>Background/Objectives:</b> In this study, a novel series of 4-(arylchalcogenyl)methyl)-1H-1,2,3-Triazol-1-yl-menadione derivatives were synthesized to explore their potential as new antituberculosis (anti-TB) agents. Selenium-containing compounds are known for their significant antimy...

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Main Authors: Nathália L. B. Santos, Luana S. Gomes, Ruan C. B. Ribeiro, Alcione S. de Carvalho, Maria Cristina S. Lourenço, Laís Machado Marins, Sandy Polycarpo Valle, Thiago H. Doring, Adriano D. Andricopulo, Aldo S. de Oliveira, Vitor F. Ferreira, Fernando de C. da Silva, Luana da Silva Magalhães Forezi, Vanessa Nascimento
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Pharmaceuticals
Subjects:
1,4-naphthoquinones
selenium
sulfur
CuAAC
<i>Mycobacterium tuberculosis</i> H37Rv (ATCC 27294)
Online Access:https://www.mdpi.com/1424-8247/18/6/797
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