Engineering and Evaluation of a Live-Attenuated Vaccine Candidate with Enhanced Type 1 Fimbriae Expression to Optimize Protection Against <i>Salmonella</i> Typhimurium

Engineering and Evaluation of a Live-Attenuated Vaccine Candidate with Enhanced Type 1 Fimbriae Expression to Optimize Protection Against <i>Salmonella</i> Typhimurium

<b>Background:</b><i>Salmonella</i> Typhimurium is a major zoonotic pathogen, in which type 1 fimbriae play a crucial role in intestinal colonization and immune modulation. This study aimed to improve the protective immunity of a previously developed growth-deficient strain—a...

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Bibliographic Details
Main Authors: Patricia García, Arianna Rodríguez-Coello, Andrea García-Pose, María Del Carmen Fernández-López, Andrea Muras, Miriam Moscoso, Alejandro Beceiro, Germán Bou
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Vaccines
Subjects:
live auxotrophic vaccines
type 1 fimbriae
FimH
mucosal vaccine
fecal IgA
<i>Salmonella</i> Typhimurium
Online Access:https://www.mdpi.com/2076-393X/13/6/659
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