Secreted retropepsin-like enzymes are essential for stress tolerance and biofilm formation in Pseudomonas aeruginosa

Secreted retropepsin-like enzymes are essential for stress tolerance and biofilm formation in Pseudomonas aeruginosa

ABSTRACT Proteases regulate important biological functions. Here, we present the structural and functional characterization of three previously uncharacterized aspartic proteases in Pseudomonas aeruginosa. We show that these proteases have structural hallmarks of retropepsin peptidases and play redu...

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Main Authors: Justin D. Lormand, Charles H. Savelle, Jennifer K. Teschler, Eva López, Richard H. Little, Jacob G. Malone, Fitnat H. Yildiz, María J. García-García, Holger Sondermann
Format: Article
Language:English
Published: American Society for Microbiology 2025-07-01
Series:mBio
Subjects:
proteases
osmotic stress
biofilms
cell shape
antibiotic resistance
Online Access:https://journals.asm.org/doi/10.1128/mbio.00872-25
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https://journals.asm.org/doi/10.1128/mbio.00872-25

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