Cartilage‐Penetrating Framework Nucleic Acid Nanoparticles Ameliorate Osteoarthritis by Promoting Drug Delivery and Chondrocyte Uptake

Cartilage‐Penetrating Framework Nucleic Acid Nanoparticles Ameliorate Osteoarthritis by Promoting Drug Delivery and Chondrocyte Uptake

Abstract Osteoarthritis (OA) is a chronic joint disease that causes a gradual deterioration of articular cartilage. A major challenge in OA treatment is the limited penetration and delivery efficiency of drugs to cartilage and chondrocytes due to the rapid clearance of drugs through synovial fluid i...

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Bibliographic Details
Main Authors: Kui Huang, Qiumei Li, Huixuan Lin, Qian Shen, Yaping Wu, Taoran Tian, Chuan Ma, Sirong Shi, Jingang Xiao, Yunfeng Lin
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
apoptosis
cartilage‐penetrating
chondrocyte uptake
framework nucleic acid nanoparticles
osteoarthritis
reactive oxygen species
Online Access:https://doi.org/10.1002/advs.202502661
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https://doi.org/10.1002/advs.202502661

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