Addressing osteoblast senescence: Molecular pathways and the frontier of anti‐ageing treatments

Addressing osteoblast senescence: Molecular pathways and the frontier of anti‐ageing treatments

Abstract Background Osteoblast senescence is a central driverof age‐related osteoporosis. Accumulating evidence shows that counteractingthis senescence can substantially mitigate bone loss. In this review, we summarize the hallmarks of osteoblast senescence, the signaling pathways involved, and ther...

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Main Authors: Zhengdong Zhang, Pan Liu, Yu Song, Liang Ma, Yan Xu, Jie Lei, Bide Tong, Dingchao Zhu, Huaizhen Liang, Hongchuan Wang, Xingyu Zhou, Zixuan Ou, Junyu Wei, Hanpeng Xu, Di Wu, Shuchang Peng, Yifan Du, Zhi Du, Bingjin Wang, Zhiwei Liao, Wencan Ke, Kangcheng Zhao, Xiqin Xia, Lei Tan, Xiaobo Feng, Gang Liu, Shuai Li, Kun Wang, Cao Yang
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Clinical and Translational Medicine
Subjects:
ageing‐related signalling pathways
anti‐ageing strategies
bone microenvironment
osteoblast senescence
SASP
Online Access:https://doi.org/10.1002/ctm2.70417
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