Synthesis, in vitro activity, and computational evaluation of novel Thiadiazole derivatives as potent urease inhibitors

A novel series of thiadiazole derivatives (6a-d) was synthesized through the cyclization of thiosemicarbazides using concentrated sulfuric acid. Structural confirmation was done by spectroscopy and elemental analysis. The synthesized compounds were evaluated for their urease inhibitory potential. To...

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Bibliographic Details
Main Authors: Naseer Ahmed, Kamran Mehdi, Obaid-ur-Rehman Abid, Saqib Khan, Adi T. Zikri, Is Helianti
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Results in Chemistry
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211715625004655
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