Targeted Biologic Therapies in Severe Asthma: Mechanisms, Biomarkers, and Clinical Applications

Targeted Biologic Therapies in Severe Asthma: Mechanisms, Biomarkers, and Clinical Applications

Asthma represents a heterogeneous disorder characterized by a dynamic balance between pro-inflammatory and anti-inflammatory forces, with allergic sensitization contributing substantially to airway hyperresponsiveness and remodeling. Central to its pathogenesis are cytokines such as IL-4, IL-5, IL-1...

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Bibliographic Details
Main Authors: Renata Maria Văruț, Dop Dalia, Kristina Radivojevic, Diana Maria Trasca, George-Alin Stoica, Niculescu Stefan Adrian, Niculescu Elena Carmen, Cristina Elena Singer
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceuticals
Subjects:
airway inflammation
cytokines
type 2 inflammation
asthma exacerbations
Online Access:https://www.mdpi.com/1424-8247/18/7/1021
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