Discovery of CA9–005 as a new carbonic anhydrase 9 inhibitor using a DNA encoded-libraries

Discovery of CA9–005 as a new carbonic anhydrase 9 inhibitor using a DNA encoded-libraries

This study utilized DNA-encoded library (DEL) screening to identify novel inhibitors of carbonic anhydrase 9 (CA9), a key cancer target. Among the identified compounds, CA9–005 exhibited inhibitory activity and reduced cancer cell viability. Biolayer interferometry confirmed CA9–005's direct in...

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Main Authors: Ju Ho Lee, Sung Bum Park, Byumseok Koh, Jiwoo Kim, Kyoung Jin Choi, Jeonghui Im, Byungho Lim, Daesoo Kim, Byungwook Lee, Sunjong Yu, Nam-Chul Cho, Doyoun Kim, Yuno Lee, Hyun Jin Kim, Ki Young Kim, Jung-Nyoung Heo
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Results in Chemistry
Subjects:
DNA-encoded libraries
DEL
Carbonic anhydrase 9
Screening
cancer inhibition
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715625004382
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Summary:This study utilized DNA-encoded library (DEL) screening to identify novel inhibitors of carbonic anhydrase 9 (CA9), a key cancer target. Among the identified compounds, CA9–005 exhibited inhibitory activity and reduced cancer cell viability. Biolayer interferometry confirmed CA9–005's direct interaction with CA9, supported by structural modeling. These findings highlight the potential of DEL screening for drug discovery and establish CA9–005 as a anticancer candidate, warranting further structural and therapeutic optimization.
ISSN:2211-7156

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