Discovery of CA9–005 as a new carbonic anhydrase 9 inhibitor using a DNA encoded-libraries

Discovery of CA9–005 as a new carbonic anhydrase 9 inhibitor using a DNA encoded-libraries

This study utilized DNA-encoded library (DEL) screening to identify novel inhibitors of carbonic anhydrase 9 (CA9), a key cancer target. Among the identified compounds, CA9–005 exhibited inhibitory activity and reduced cancer cell viability. Biolayer interferometry confirmed CA9–005's direct in...

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Bibliographic Details
Main Authors: Ju Ho Lee, Sung Bum Park, Byumseok Koh, Jiwoo Kim, Kyoung Jin Choi, Jeonghui Im, Byungho Lim, Daesoo Kim, Byungwook Lee, Sunjong Yu, Nam-Chul Cho, Doyoun Kim, Yuno Lee, Hyun Jin Kim, Ki Young Kim, Jung-Nyoung Heo
Format: Article
Language:English
Published: Elsevier 2025-07-01
Series:Results in Chemistry
Subjects:
DNA-encoded libraries
DEL
Carbonic anhydrase 9
Screening
cancer inhibition
Online Access:http://www.sciencedirect.com/science/article/pii/S2211715625004382
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http://www.sciencedirect.com/science/article/pii/S2211715625004382

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