Enhancing chemosensitivity of PANC1 pancreatic cancer cells to gemcitabine using ANGTPL4, Notch1 and NF-κβ1 siRNAs

Enhancing chemosensitivity of PANC1 pancreatic cancer cells to gemcitabine using ANGTPL4, Notch1 and NF-κβ1 siRNAs

Aim: siRNA can silence targeted genes with lesser toxicity than therapeutic drugs. Therefore, this study aims to investigate new approaches to treat pancreatic cancer (PC) using combinations of siRNA and gemcitabine. Methods: Three genes, ANGTPL4, Notch1 and NF-κβ1, were silenced using siRNA, and th...

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Bibliographic Details
Main Authors: Abdulfattah Al-Kadash, Walhan Alshaer, Ismail Sami Mahmoud, Suha Wehaibi, Malek Zihlif
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Future Science OA
Subjects:
ANGPTL4
gemcitabine
NF-κβ1
Notch1
pancreatic cancer
siRNA
Online Access:https://www.tandfonline.com/doi/10.2144/fsoa-2023-0145
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https://www.tandfonline.com/doi/10.2144/fsoa-2023-0145

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