CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype

CCDC80 Protects against Aortic Dissection and Rupture by Maintaining the Contractile Smooth Muscle Cell Phenotype

Abstract Aortic dissection (AD) is a life‐threatening medical emergency characterized by adverse vascular remodeling. Coiled‐coil domain‐containing protein 80 (CCDC80) plays an essential role in regulating cardiovascular remodeling. This study aims to define the role of CCDC80 in the formation and d...

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Bibliographic Details
Main Authors: Qingqing Xiao, Yi Li, Bin Cai, Xiying Huang, Liang Fang, Feng Liang, Long Chen, Ke Xu, Weifeng Zhang, Xiaolei Wang, Anwen Yin, Xia Wang, Zhaohua Cai, Fei Zhuang, Qin Shao, Bin Zhou, Berthold Hocher, Ben He, Linghong Shen
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Advanced Science
Subjects:
aortic dissection
CCDC80
JAK2/STAT3 signaling pathway
vascular remodeling
VSMC phenotype switching
Online Access:https://doi.org/10.1002/advs.202502108
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