Beyond proofreading: POLD1 mutations as dynamic orchestrators of genomic instability and immune evasion in cancer
DNA polymerase delta (Pol δ) is a cornerstone of genomic stability, orchestrating DNA replication and repair through its catalytic subunit, POLD1. This subunit’s 3’–5’ exonuclease domain proofreads replication errors, ensuring fidelity. However, POLD1 mutations—particularly in this domain—disrupt th...
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| Ngā kaituhi matua: | , , , , , |
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| Hōputu: | Tuhinga |
| Reo: | Ingarihi |
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Frontiers Media S.A.
2025-06-01
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| Rangatū: | Frontiers in Immunology |
| Ngā marau: | |
| Urunga tuihono: | https://www.frontiersin.org/articles/10.3389/fimmu.2025.1600233/full |
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