Research of some sides of antifungal activity mechanism act of new adamantane derivative
Mechanism of the antiviral action of adamantane-containing preparations caused by their membranotropic properties. In the screening studies we discovered the substance 4-adamantyl-1(1-aminobutil) benzene (substance AM-166) with the wide spectrum of antimicrobic action. AM-166 suppresses increase and...
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| Format: | Article |
| Language: | English |
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State Institution "Dnipro State Medical University"
2009-01-01
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| Series: | Морфологія |
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| Online Access: | http://www.morphology.dp.ua/_pub/MORPHO-2009-03-02/09vnonpa.pdf |
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| author | Vrynchanu N.A. Sergienko O.V. Maksimov Yu. N. |
| author_facet | Vrynchanu N.A. Sergienko O.V. Maksimov Yu. N. |
| author_sort | Vrynchanu N.A. |
| collection | DOAJ |
| description | Mechanism of the antiviral action of adamantane-containing preparations caused by their membranotropic properties. In the screening studies we discovered the substance 4-adamantyl-1(1-aminobutil) benzene (substance AM-166) with the wide spectrum of antimicrobic action. AM-166 suppresses increase and multiplication of bacteria (aerobic, anaerobic) and fungi (yeast like, mold and dermatomyces). The ointment for treating the pyoinflammatory processes was developed on the basis of adamantane-containing substance. The purpose of our experiments was to learn some sides of the mechanism of the antifungal action of substance AM-166 at the ultramicroscopic level. Experiments were carried out on the Candida albicans NCTC885/653. Substance concentration was 4 MIC. Ultrathin sections obtained on the ultratome LKB-880 U and contrasted by acetate of uranyl and by citrate of lead, were investigated in the electron microscope EM-125 K. It is established, that the substance AM-166 in concentration 4 MIC causes the damage of cell wall and cytoplasmic structures of the yeast-like fungus of C.albicans. These disturbances were recorded after 1 h of incubation with the substance AM-166. Thus, our experiments showed that the inhibiting action of adamantane-containing substance is caused, first of all, by influence on the cellular mem-brane of fungus. |
| format | Article |
| id | doaj-art-36f1f2dee9c74a8d9a5c2d0e05811a7c |
| institution | Matheson Library |
| issn | 1997-9665 |
| language | English |
| publishDate | 2009-01-01 |
| publisher | State Institution "Dnipro State Medical University" |
| record_format | Article |
| series | Морфологія |
| spelling | doaj-art-36f1f2dee9c74a8d9a5c2d0e05811a7c2025-08-02T05:16:10ZengState Institution "Dnipro State Medical University"Морфологія1997-96652009-01-01322427Research of some sides of antifungal activity mechanism act of new adamantane derivativeVrynchanu N.A.Sergienko O.V.Maksimov Yu. N.Mechanism of the antiviral action of adamantane-containing preparations caused by their membranotropic properties. In the screening studies we discovered the substance 4-adamantyl-1(1-aminobutil) benzene (substance AM-166) with the wide spectrum of antimicrobic action. AM-166 suppresses increase and multiplication of bacteria (aerobic, anaerobic) and fungi (yeast like, mold and dermatomyces). The ointment for treating the pyoinflammatory processes was developed on the basis of adamantane-containing substance. The purpose of our experiments was to learn some sides of the mechanism of the antifungal action of substance AM-166 at the ultramicroscopic level. Experiments were carried out on the Candida albicans NCTC885/653. Substance concentration was 4 MIC. Ultrathin sections obtained on the ultratome LKB-880 U and contrasted by acetate of uranyl and by citrate of lead, were investigated in the electron microscope EM-125 K. It is established, that the substance AM-166 in concentration 4 MIC causes the damage of cell wall and cytoplasmic structures of the yeast-like fungus of C.albicans. These disturbances were recorded after 1 h of incubation with the substance AM-166. Thus, our experiments showed that the inhibiting action of adamantane-containing substance is caused, first of all, by influence on the cellular mem-brane of fungus.http://www.morphology.dp.ua/_pub/MORPHO-2009-03-02/09vnonpa.pdfderivatives of adamantanemicroorganismsCandida albicanscell wall |
| spellingShingle | Vrynchanu N.A. Sergienko O.V. Maksimov Yu. N. Research of some sides of antifungal activity mechanism act of new adamantane derivative Морфологія derivatives of adamantane microorganisms Candida albicans cell wall |
| title | Research of some sides of antifungal activity mechanism act of new adamantane derivative |
| title_full | Research of some sides of antifungal activity mechanism act of new adamantane derivative |
| title_fullStr | Research of some sides of antifungal activity mechanism act of new adamantane derivative |
| title_full_unstemmed | Research of some sides of antifungal activity mechanism act of new adamantane derivative |
| title_short | Research of some sides of antifungal activity mechanism act of new adamantane derivative |
| title_sort | research of some sides of antifungal activity mechanism act of new adamantane derivative |
| topic | derivatives of adamantane microorganisms Candida albicans cell wall |
| url | http://www.morphology.dp.ua/_pub/MORPHO-2009-03-02/09vnonpa.pdf |
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