Divergent sex-specific effects on a ketogenic diet: Male, but not female, mice exhibit oxidative stress and cellular senescence

Divergent sex-specific effects on a ketogenic diet: Male, but not female, mice exhibit oxidative stress and cellular senescence

Summary: While a ketogenic diet (KD) can improve certain health parameters, evidence from murine and clinical studies suggests that these effects may be dependent on multiple variables. One understudied variable is the role of sex in the response to a KD. Here, we show that a KD-induced increase in...

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Main Authors: Sung-Jen Wei, Joseph Schell, Wei Qian, Martin Silguero, Agne Baseviciene, Wan Hsi Chen, Rolando Trevino, Jr., E. Sandra Chocron, Meredith M. Ogle, Mahboubeh Varmazyad, Gloria M. Martinez, Diego Cruz, Brandon Lorenzana, Felix F. Dong, Haiyan Jiang, Alia Nazarullah, Robert A. Beardsley, Kumar Sharma, Jenny Chang, Erin Munkácsy, Nobuo Horikoshi, David Gius
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Cell Reports
Subjects:
CP: Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124725007971
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http://www.sciencedirect.com/science/article/pii/S2211124725007971

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