The diabetes gene Tcf7l2 organizes gene expression in the liver and regulates amino acid metabolism

The diabetes gene Tcf7l2 organizes gene expression in the liver and regulates amino acid metabolism

Objective: Though Tcf7l2 harbors the strongest genetic association with diabetes identified thus far, how it promotes metabolic disease remains unclear. Our aim was to dissect the contribution of hepatic TCF7L2. Methods: Mice with liver-specific knockout of Tcf7l2 produced by targeted deletion of ex...

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Main Authors: Joanna Krawczyk, William O’Connor, Pedro Vendramini, Mareike Schell, Kiran J. Biddinger, Matt Kanke, George Pengo, Ivana Semova, Tiffany Fougeray, Marcia Haigis, Krishna G. Aragam, Wouter H. Lamers, Linus T. Tsai, Praveen Sethupathy, Sudha B. Biddinger
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Molecular Metabolism
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Transcription
Diabetes
Metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877825001152
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