Lipidomics Unveils Critical Lipid Pathway Shifts in Alport Syndrome

Lipidomics Unveils Critical Lipid Pathway Shifts in Alport Syndrome

Introduction: Alport syndrome (AS) is a hereditary kidney disease from COL4A3–5 pathogenic variants causing glomerular basement membrane abnormalities. Although genetic and structural aspects are known, mechanisms linking collagen IV defects to podocyte injury are unclear. Lipotoxicity and lipid dys...

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Main Authors: Belen Requena, Amir Shabaka, Borja Lanzon, Sara Martinez, Isabel Galan Carrillo, Teresa Bada-Bosch, Angel Sevillano, Ana Maria Tato-Ribera, Coral Barbas, Gema Medina-Gomez, Carolina Gonzalez-Riano, Gema Fernandez-Juarez
Format: Article
Language:English
Published: Elsevier 2025-08-01
Series:Kidney International Reports
Subjects:
Alport syndrome
diabetic kidney disease
genetic kidney disease
lipid profiling
lipidomics
Online Access:http://www.sciencedirect.com/science/article/pii/S2468024925003377
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http://www.sciencedirect.com/science/article/pii/S2468024925003377

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