Trans-cinnamaldehyde ameliorates neuroinflammation-mediated synaptic plasticity and memory impairment by blocking TLR4/MyD88/MAPKs pathway in global cerebral ischemia

Trans-cinnamaldehyde ameliorates neuroinflammation-mediated synaptic plasticity and memory impairment by blocking TLR4/MyD88/MAPKs pathway in global cerebral ischemia

Global cerebral ischemia (GCI), a severe form of ischemic stroke, leads to significant cognitive and neurological deficits, with neuroinflammation playing a central role in its pathophysiology. Trans-cinnamaldehyde (TCA), derived from Cinnamomum cassia (L.), has demonstrated anti-inflammatory and ne...

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Bibliographic Details
Main Authors: Xinjuan Liu, Zhiyuan Lu, Gaiying He, Waimao Gao, Kaifan Hu, Jie Pan, Yan Zhao, Xingyu Wang, Guang Yang, Ying Xu
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Brain Research Bulletin
Subjects:
Trans-cinnamaldehyde
Global cerebral ischemia
Synaptic plasticity
Microglia activation
TLR4/MyD88/MAPKs pathway
Online Access:http://www.sciencedirect.com/science/article/pii/S0361923025002680
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http://www.sciencedirect.com/science/article/pii/S0361923025002680

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