Resveratrol-derived MDM2 inhibitors: Synthesis, characterization, and biological evaluation against MDM2 and HCT-116 cells

Resveratrol-derived MDM2 inhibitors: Synthesis, characterization, and biological evaluation against MDM2 and HCT-116 cells

This study investigates the biological potential of novel resveratrol-based derivatives targeting the MDM2 protein, a critical regulator of the tumour suppressor p53 in cancer therapy. We synthesized and characterized four derivatives of (E)-2,4-dimethoxy-6-(4-methoxystyryl) benzaldehyde using mass...

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Bibliographic Details
Main Authors: Oraibi Amjad Ibrahim, Dawood Ashour H., Debbabi Nawres, Almukram Ali Majeed Ali, Almaary Khalid S., Dabiellil Fakhreldeen, Chekir-Ghedira Leila, Kilani-Jaziri Soumaya
Format: Article
Language:English
Published: De Gruyter 2025-07-01
Series:Open Chemistry
Subjects:
mdm2
cancer
protein p53
molecular docking
molecular dynamics
Online Access:https://doi.org/10.1515/chem-2025-0142
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https://doi.org/10.1515/chem-2025-0142

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