Fetal hemoglobin enables malaria parasite growth in sickle cells but augments production of transmission stage parasites.

Fetal hemoglobin enables malaria parasite growth in sickle cells but augments production of transmission stage parasites.

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Sickle cell trait is the quintessential example of the human evolutionary response to malaria, providing protection against severe disease, but leading to sickle cell disease (SCD) in the homozygous state. Fetal Hemoglobin (HbF) reduces the pathology of SCD and several mutations lead to the prolonge...

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Main Authors: Catherine Lavazec, Cheikh Loucoubar, Florian Dupuy, Jean-François Bureau, Isabelle Casadémont, Bronner Gonçalves, Swee Lay Thein, Mark Lathrop, Sandrine Laurance, Camille Roussel, Caroline Le Van Kim, Yves Colin, Mariane De Montalembert, Anavaj Sakuntabhai, Richard E Paul
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0325797
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https://doi.org/10.1371/journal.pone.0325797

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