A novel thiazole-sulfonamide hybrid molecule as a promising dual tubulin/carbonic anhydrase IX inhibitor with anticancer activity

A novel thiazole-sulfonamide hybrid molecule as a promising dual tubulin/carbonic anhydrase IX inhibitor with anticancer activity

IntroductionMultitargeted anticancer agents can overcome resistance by simultaneously modulating key pathways. This study reports a novel thiazole -chalcone/sulfonamide hybrid (compound 7) designed to inhibit both tubulin polymerization and carbonic anhydrase IX (CA IX).MethodsCompound 7 was synthes...

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Bibliographic Details
Main Authors: Hussam Elddin Nabeih Khasawneh, Elryah I. Ali, Ranya Mohammed Elmagzoub, Raed Fanoukh Aboqader Al-Aouadi, Wesam Taher Almagharbeh, Ghallab Alotaibi, Stefan Bräse, Abdullah Alkhammash
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Chemistry
Subjects:
thiazole
chalcone
sulphonamide
tubulin
carbonic anhydrase
cytotoxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2025.1606848/full
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https://www.frontiersin.org/articles/10.3389/fchem.2025.1606848/full

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