Epigenetic Rewiring of Protein Kinase Signalling in T-Cell Acute Lymphoblastic Leukaemia

Epigenetic Rewiring of Protein Kinase Signalling in T-Cell Acute Lymphoblastic Leukaemia

T-cell acute lymphoblastic leukaemia (T-ALL) is an aggressive neoplastic malignancy characterised by the accumulation of multiple oncogenic and epigenetic alterations in haematopoietic T-cell precursors leading to their uncontrolled proliferation and accumulation in the bone marrow. For many years i...

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Bibliographic Details
Main Authors: Claudina A. Pérez-Novo, Amber Driesen, Maaike Van Trimpont, Claudia Theys, Emilie Logie, Pieter Van Vlierberghe, Wim Vanden Berghe
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Kinases and Phosphatases
Subjects:
protein kinases
T-cell acute lymphoblastic leukaemia
histone modifications
DNA methylation
microRNAs
epigenetics
Online Access:https://www.mdpi.com/2813-3757/3/2/7
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