The mitochondrial methylation potential gates mitoribosome assembly

The mitochondrial methylation potential gates mitoribosome assembly

Abstract S-adenosylmethionine (SAM) is the principal methyl donor in cells and is essential for mitochondrial gene expression, influencing RNA modifications, translation, and ribosome biogenesis. Using direct long-read RNA sequencing in mouse tissues and embryonic fibroblasts, we show that processin...

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Main Authors: Ruth I. C. Glasgow, Vivek Singh, Lucía Peña-Pérez, Alissa Wilhalm, Marco F. Moedas, David Moore, Florian A. Rosenberger, Xinping Li, Ilian Atanassov, Mira Saba, Miriam Cipullo, Joanna Rorbach, Anna Wedell, Christoph Freyer, Alexey Amunts, Anna Wredenberg
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60977-x
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https://doi.org/10.1038/s41467-025-60977-x

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