Cardioprotective Effects of Bosentan in Rats Subjected to Lung Ischemia–Reperfusion Injury

Cardioprotective Effects of Bosentan in Rats Subjected to Lung Ischemia–Reperfusion Injury

<i>Objective</i>: This study aimed to investigate the cardioprotective effects of bosentan, an endothelin receptor antagonist, in a rat model of lung ischemia–reperfusion (I/R) injury, with a focus on myocardial tissue involvement. <i>Methods</i>: Twenty-four male Wistar rats...

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Main Authors: Şevki Mustafa Demiröz, Ayşegül Küçük, Esra Tekin, Sibel Söylemez, Hanife Yılmaz, Şaban Cem Sezen, Muharrem Atlı, Hüseyin Demirtaş, Abdullah Özer, Yusuf Ünal, Mustafa Arslan
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Medicina
Subjects:
bosentan
lung ischemia–reperfusion
cardioprotection
oxidative stress
endothelin-1
myocardial injury
Online Access:https://www.mdpi.com/1648-9144/61/7/1298
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https://www.mdpi.com/1648-9144/61/7/1298

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